Wnt Signaling Pathway Is among the Drivers of Liver Metastasis

Liver metastasis, originating either from a primary liver or other cancer types, represent large cancer-related burden. Therefore, studies that add to better understanding of its molecular basis are needed. Herein, the role Wnt signaling pathway in metastasis is outlined. Its hepatocellular carcinoma (HCC) epithelial-mesenchymal transition (EMT), motility, migration, formation, and steps metastatic cascade presented. Additionally, roles formation colorectal, breast, gastric, lung, melanoma, pancreatic, prostate explored. The special emphasis given communication between many components secondary microenvironment contribute outgrowth liver. data presented herein review most recent publications advances field idea among drivers targeting could potentially relieve metastasis–related complications.